Published onApril 12, 2026How to Choose an Agent Framework: A Practical Comparison of the Mainstream OptionsaiagentsframeworksarchitecturefullstackCompares mainstream agent frameworks including OpenAI Agents SDK, LangChain/LangGraph, CrewAI, Google ADK, Microsoft Agent Framework, AutoGen, Semantic Kernel, LlamaIndex, PydanticAI, and Mastra, with guidance on tradeoffs and fit.